期刊
CURRENT OPINION IN VIROLOGY
卷 26, 期 -, 页码 63-68出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2017.07.015
关键词
-
类别
资金
- Intramural Research Program of the NIAID, NIH
Papillomaviruses are small DNA viruses that replicate persistently in the stratified epithelial surfaces of the host. They have minimal coding capacity and must hijack many cellular processes to complete their life cycle. For example, viral genomes are tethered to host chromatin to ensure that they are effectively partitioned in dividing cells, and the host DNA damage and repair pathways are usurped to replicate viral DNA in differentiated cells. These processes result in the close juxtaposition of viral DNA with host DNA that is undergoing replication stress. This could explain the propensity of oncogenic human papillomaviruses (HPVs) to accidently integrate into common fragile sites in host DNA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据