期刊
CURRENT OPINION IN VIROLOGY
卷 22, 期 -, 页码 77-88出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coviro.2016.12.001
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资金
- Australian National Health and Medical Research Council (NHMRC) Program [AI1071916]
- Melbourne International Fee Remission Scholarship (MIFRS)
- Melbourne International Research Scholarship (MIRS)
- Victoria India Doctoral Scholarship (VIDS)
- MIFRS
CD27 is a co-stimulatory immune-checkpoint receptor, constitutively expressed on a broad range of T-cells (alpha beta and gamma delta), NK-cells and B-cells. Ligation of CD27 with CD70 results in potent co-stimulatory effects. In mice, co-stimulation of CD8(+) T-cells through CD27 promotes immune activation and enhances primary, secondary, memory and recall responses towards viral infections. Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent costimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour immunotherapies. This review focuses on the role of CD27 co-stimulation in anti-viral T-cell immunity and discusses clinical studies utilising the CD27 co-stimulation pathway for anti-viral, anti-tumour and autoimmune immunotherapy.
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