Enhance the Bioactivity and Osseointegration of the Polyethylene-Terephthalate-Based Artificial Ligament via Poly(Dopamine) Coating with Mesoporous Bioactive Glass

The objective of this study is to study the bioactivity and osseointegration of polyethylene-terephthalate-based artificial ligament coated with mesoporous bioactive glass (MBG) via polydopamine (PDA) in vitro and in vivo. In vitro, the OD value of MC3T3-E1 cells on PDA-MBG modified grafts is around 108% higher than that on pure PET after 5 days of culturing. The ALP activity of the PDA-MBG group is about 1.5 times higher than that of the control group after 7 days of culturing. In the in vivo study, the results demonstrated that more newly formed bone tissue was found and the ultimate failure load increased in the PDA-MBG coating group. In conclusion, PDA and MBG coating improves the surface bioactivity of the polyethylene-terephthalate-based artificial ligament and enhances the osseointegration within a bone tunnel.