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Atrx promotes heterochromatin formation at retrotransposons
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Alternative lengthening of tetomeres phenotype in malignant vascular tumors is highly associated with toss of ATRX expression and is frequently observed in hepatic angiosarcomas
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Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas
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NATURE (2015)
TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors
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Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors
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SCIENCE (2015)
Molecular Markers in Low-Grade Glioma-Toward Tumor Reclassification
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Emerging roles of ATRX in cancer
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Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX
David Clynes et al.
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ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes
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CELL REPORTS (2015)
ATRX promotes gene expression by facilitating transcriptional elongation through guanine-rich coding regions
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HUMAN MOLECULAR GENETICS (2015)
Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma
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Oncotarget (2015)
Leiomyosarcoma With Alternative Lengthening of Telomeres Is Associated With Aggressive Histologic Features, Loss of ATRX Expression, and Poor Clinical Outcome
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CANCER CELL (2014)
ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets
Kavitha Sarma et al.
CELL (2014)
Decreased Expression of the Chromatin Remodeler ATRX Associates with Melanoma Progression
Zulekha A. Qadeer et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)
Integrated genomic characterization of adrenocortical carcinoma
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The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
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NATURE GENETICS (2014)
Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells
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SCIENCE (2014)
Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation
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SCIENCE (2014)
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CELL REPORTS (2014)
Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
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CANCER CELL (2013)
ATRX and the replication of structured DNA
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CURRENT OPINION IN GENETICS & DEVELOPMENT (2013)
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
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Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly
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HUMAN MOLECULAR GENETICS (2013)
Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX Is Required for Proper Replication Restart and Cellular Resistance to Replication Stress
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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span
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JOURNAL OF CLINICAL INVESTIGATION (2013)
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SCIENCE (2013)
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TRENDS IN BIOCHEMICAL SCIENCES (2013)
Neuroblastoma: developmental biology, cancer genomics and immunotherapy
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NATURE REVIEWS CANCER (2013)
Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations
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ACTA NEUROPATHOLOGICA (2012)
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
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ACTA NEUROPATHOLOGICA (2012)
ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression
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GENES & DEVELOPMENT (2012)
Association of Age at Diagnosis and Genetic Mutations in Patients With Neuroblastoma
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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)
Compromised genomic integrity impedes muscle growth after Atrx inactivation
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JOURNAL OF CLINICAL INVESTIGATION (2012)
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Chao Lu et al.
NATURE (2012)
DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition
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NATURE (2012)
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
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NATURE (2012)
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NATURE (2012)
Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
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NATURE (2012)
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
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NATURE GENETICS (2012)
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PLOS ONE (2012)
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COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway
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Analysis of the human HP1 interactome reveals novel binding partners
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome
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HUMAN MOLECULAR GENETICS (2011)
The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9
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HUMAN MOLECULAR GENETICS (2011)
Functional significance of mutations in the Snf2 domain of ATRX
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HUMAN MOLECULAR GENETICS (2011)
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin
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NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Gain, Loss and Divergence in Primate Zinc-Finger Genes: A Rich Resource for Evolution of Gene Regulatory Differences between Species
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PLOS ONE (2011)
Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease
Rabindranath De La Fuente et al.
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Altered Telomeres in Tumors with ATRX and DAXX Mutations
Christopher M. Heaphy et al.
SCIENCE (2011)
DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors
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SCIENCE (2011)
Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
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CELL (2010)
ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner
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CELL (2010)
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3
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GENES & DEVELOPMENT (2010)
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
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Epigenetic regulation of telomere chromatin integrity in pluripotent embryonic stem cells
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Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome
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Mutations in the chromatin-associated protein ATRX
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HUMAN MUTATION (2008)
Mutations in PHD-like domain of the ATRX gene correlate with severe psychomotor impairment and severe urogenital abnormalities in patients with ATRX syndrome
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Alpha thalassaemia-mental retardation, X linked
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Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues
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The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis
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JOURNAL OF CLINICAL INVESTIGATION (2005)
Prevalence of quadruplexes in the human genome
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Resolution of sister telomere association is required for progression through mitosis
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Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis
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CELL (2004)
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J Tang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies
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NATURE GENETICS (2003)
The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly
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Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association
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HUMAN MOLECULAR GENETICS (2000)
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