期刊
ACS NANO
卷 11, 期 5, 页码 4848-4858出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b01346
关键词
nanocomposites; targeting; radiochemotherapy; radiosentization; cancer therapy
类别
资金
- Science Foundation for Distinguished Young Scholars of Guangdong Province [2013050014667]
- Natural Science Foundation of China [21371076]
- National High-level personnel of special support program [2014189]
- YangFan Innovative & Entepreneurial Research Team Project [201312H05]
- Guangdong Special Support Program
- Guangdong Frontier Key Technological Innovation Special Funds [2014B050505012]
- Fundamental Research Funds for the Central Universities
- Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [City U11301215]
Radiotherapy is an important regime for treating malignant tumors. There is interest in the development of radiosensitizers to increase the local treatment efficacy under a relatively low and safe radiation dose. In this study, we designed Au@Se-R/A nanocomposites (Au@Se-R/A NCs) as nano-radiosensitizer to realize synergistic radiochemotherapy based on the radiotherapy sensitization property of Au nanorods (NRs) and antitumor activity of Se NPs. In vitro studies show that the combined treatment of A375 melanoma cells in culture with NCs and X-ray induces cell apoptosis through alteration in expression of p53 and DNA-damaging genes and triggers intracellular ROS overproduction, leading to greatly enhanced anticancer efficacy. Further studies using clinically used radiotherapy equipment demonstrate that the combined treatment of NCs and X-ray significantly inhibits the tumor growth in vivo and shows negligible acute toxicity to the major organs. Taken together, this study provides a strategy for clinical translation application of nanomedicne in cancer radiochemotherapy.
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