期刊
CHEMPLUSCHEM
卷 82, 期 6, 页码 826-833出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201600586
关键词
hydrogels; isoguanosine; nucleosides; selfassembly; supramolecular chemistry
资金
- ChemBiotech, Munster, Germany
- China Scholarship Council (CSC), Beijing
Supramolecular nucleoside-based hydrogels have the potential to be utilized in drug delivery, regenerative medicine and for the construction of nanoscopic devices. Isoguanosine, its 2'-deoxyribonucleoside and the 2'-deoxy-2'-fluororibonucleoside form hydrogels in alkali metal salt solutions. Gel stability depends on the metal ions used (Li+, Na+, K+, Rb+, Cs+). All isoguanosine gels show long-term stability of several months, whereas guanosine gels collapse within minutes or hours. Rheological data confirm a 15 times higher hydrogel stability for isoguanosine compared to guanosine. Isoguanosine gel stability covers a broad pH range (pH 3-10), and the stability at physiological Na+ ion concentration is striking. SEM images reveal that isoguanosine self-assembles into helical stacked fibers that are interconnected whereas guanosine forms discrete ribbons. Moreover, isoguanosine gels display excellent loading and release ability for small molecules.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据