期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 19, 页码 5353-5357出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201701918
关键词
biaryls; C-H activation; copper; decarboxylation; synthetic methods
资金
- JSPS [JP 15K13696, JP 15H05485, JP 24225002]
- Grants-in-Aid for Scientific Research [15K13696, 15H05485, 17J00349] Funding Source: KAKEN
A copper-mediated decarboxylative coupling of benzamides with ortho-nitrobenzoic acids by 8-aminoquinoline-directed C-H cleavage has been developed. This reaction proceeds smoothly with only a copper salt to produce the corresponding biaryl compounds in good yields. The products can be easily transformed into various nitrogen-containing heterocyclic compounds. Moreover, the combination of copper and a suitable base promotes a decarboxylative C-H arylation and cyclization sequence to deliver phenanthridinone derivatives in one pot.
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