期刊
CHEMPLUSCHEM
卷 82, 期 4, 页码 638-646出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201700052
关键词
iron oxide nanoparticles; multimodal imaging; protein corona; proteomics; zwitterions
资金
- Helmholtz Initiative and Networking Fund (Functional Nanomaterials for Multimodality Cancer Imaging (NanoTracking) [VH-VI-421]
- Australian Research Council [FT130100838]
- Alexander von Humboldt Foundation
- [DP130100816]
Polyacrylic-acid-coated ultra-small super-paramagnetic iron oxide nanoparticles were surface-modified with low-molecular-weight sulfobetaines or 3-(diethylamino) propylamine in order to generate nanoparticles with zwitterionic character (ZW-NPs). The ZW-NPs proved highly resistant to serum protein corona formation in vitro, as revealed by atomic force microscopy, SDS-PAGE and proteomics analysis, and exhibited low cytotox-icity towards A431 and HEK293 cells. The presence of unreacted carboxylic acid groups enabled additional functionalization with fluorescent (Cy5) and radioactive [Cu-64-dmptacn; dmptacn= 1,4-bis(2-pyridinylmethyl)-1,4,7-triazacyclononane] moieties. Overall, the ZW-NPs represent promising platforms for the development of new multimodal diagnostic/ therapeutic agents possessing stealth properties.
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