期刊
CELL REPORTS
卷 18, 期 2, 页码 391-405出版社
CELL PRESS
DOI: 10.1016/j.celrep.2016.12.041
关键词
-
类别
资金
- Medical Research Council [MR/K022687/1]
- Spanish Ministry of Economy and Competitiveness
- FEDER funds [BFU2015-66689, RYC-2013-12817]
- Alzheimer Forschung Initiative e.V
- Medical Research Council [MR/K022687/1, MR/N026039/1] Funding Source: researchfish
- MRC [MR/K022687/1, MR/N026039/1] Funding Source: UKRI
Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived andmaintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the turnover of microglia is remarkably fast, allowing the whole population to be renewed several times during a lifetime. The number of microglial cells remains steady from late postnatal stages until aging and is maintained by the spatial and temporal coupling of proliferation and apoptosis, as shown by pulse-chase studies, chronic in vivo imaging of microglia, and the use of mouse models of dysregulated apoptosis. Our results reveal that the microglial population is constantly and rapidly remodeled, expanding our understanding of its role in the maintenance of brain homeostasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据