期刊
CELL REPORTS
卷 20, 期 11, 页码 2565-2574出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.08.056
关键词
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类别
资金
- NIH [R37 HL63762, RF1 AG053391]
- NINDS/NIA [R01 NS093382, P30 AG12300, HL20948, R01 NS079796]
- Consortium for Frontotemporal Dementia Research
- Bright Focus Foundation
- Alzheimer Association
- Carl B. and Florence E. King Foundation Endowed Fund in Alzheimer's Disease Research
- Clayton Foundation for Research
Defective lysosomal function defines many neurodegenerative diseases, such as neuronal ceroid lipofuscinoses (NCL) and Niemann-Pick type C (NPC), and is implicated in Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD-TDP) with progranulin (PGRN) deficiency. Here, we show that PGRN is involved in lysosomal homeostasis and lipid metabolism. PGRN deficiency alters lysosome abundance and morphology in mouse neurons. Using an unbiased lipidomic approach, we found that brain lipid composition in humans and mice with PGRN deficiency shows disease-specific differences that distinguish them from normal and other pathologic groups. PGRN loss leads to an accumulation of polyunsaturated triacylglycerides, as well as a reduction of diacylglycerides and phosphatidylserines in fibroblast and enriched lysosome lipidomes. Transcriptomic analysis of PGRN-deficient mouse brains revealed distinct expression patterns of lysosomal, immune-related, and lipid metabolic genes. These findings have implications for the pathogenesis of FTLD-TDP due to PGRN deficiency and suggest lysosomal dysfunction as an underlying mechanism.
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