期刊
CELL REPORTS
卷 20, 期 2, 页码 344-355出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.06.040
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资金
- Margaret Q. Landenberger Research Foundation
- Hassel Family Foundation
- NIH [NS085171, F30-AG048710]
Alzheimer's disease (AD) is characterized by cognitive decline and 5-to10- fold increased seizure incidence. How seizures contribute to cognitive decline in AD or other disorders is unclear. We show that spontaneous seizures increase expression of Delta FosB, a highly stable Fos-family transcription factor, in the hippocampus of an AD mouse model. DFosB suppressed expression of the immediate early gene c-Fos, which is critical for plasticity and cognition, by binding its promoter and triggering histone deacetylation. Acute histone deacetylase (HDAC) inhibition or inhibition of DFosB activity restored c-Fos induction and improved cognition in AD mice. Administration of seizure-inducing agents to nontransgenic mice also resulted in Delta FosB-mediated suppression of c-Fos, suggesting that this mechanism is not confined to AD mice. These results explain observations that c-Fos expression increases after acute neuronal activity but decreases with chronic activity. Moreover, these results indicate a general mechanism by which seizures contribute to persistent cognitive deficits, even during seizure-free periods.
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