期刊
CELL REPORTS
卷 18, 期 11, 页码 2566-2575出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.02.061
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资金
- Swiss National Science Foundation (SNSF) [310030_159491, CRSII2_127547]
- Novartis Stiftung fur Medizinisch-Biologische Forschung [12A09]
- Nano-Tera Project [20NA21_128841]
- Fondazione Ticinese per la Ricerca sul Cancro
- Fondazione per la Ricerca sulla Trasfusione e sui Trapianti and Converge Biotech
- Signora Alessandra
- MD-PhD-Programm [SNF323530_158124]
- SNSF [SNSF310030_134902]
- European Research Council (FP) [281785]
- Swiss National Science Foundation (SNF) [CRSII2_127547, 310030_159491] Funding Source: Swiss National Science Foundation (SNF)
- European Research Council (ERC) [281785] Funding Source: European Research Council (ERC)
The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help.
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