期刊
CELL REPORTS
卷 21, 期 9, 页码 2433-2446出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.11.006
关键词
-
类别
资金
- La Ligue Nationale contre le Cancer
- Fondation ARC (Association pour la Recherche sur le Cancer)
- French Ministry of Science
- Ligue Nationale Contre le Cancer
- Fondation ARC
- FRM (Fondation pour la Recherche Medicale)
- ANR (Agence Nationale de la Recherche, Pings program)
- INCa (Institut National du Cancer, PLBIO) [2012-123]
- Fondation ARC (Progamme ARC) [PGA120150202320]
Antisense RNAs are non-coding RNAs that can regulate their corresponding sense RNAs and are generally produced from specific promoters. We uncover here a family of antisense RNAs, named START RNAs, produced during cellular senescence by transcriptional read-through at convergent protein-coding genes. Importantly, START RNAs repress the expression of their corresponding sense RNAs. In proliferative cells, we found that the Pol II elongation rate is limited downstream of TTS at START loci, allowing transcription termination to occur before Pol II reaches the convergent genes, thus preventing antisense RNA production and interference with the expression of the convergent genes. START RNAs are repressed by H2A. Z histone variant, whose local occupancy decreases in senescence. Our results thus uncover a mechanism of gene expression regulation relying on read-through antisense transcript production at convergent genes, underlining the functional importance of chromatin regulation in the control of RNA pol II elongation rate at intergenic regions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据