期刊
CELL REPORTS
卷 18, 期 11, 页码 2584-2591出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.02.062
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资金
- Intramural Research Program of NIDA, NIH
- Tobacco-Related Disease Research Program
- NIDA-INSERM postdoctoral fellowship program
- Swedish Research Council [2013-4657, 2014-3804]
- Swedish Brain Foundation
- Research Foundation of Bertil Hallsten
- Research Foundation of Ahlen
- Parkinsonfonden
- [R01DA036612]
Dopamine neurons in the ventral tegmental area (VTA) were previously found to express vesicular glutamate transporter 2 (VGLUT2) and to co-transmit glutamate in the ventral striatum (VStr). This capacity may play an important role in reinforcement learning. Although it is known that activation of the VTA-VStr dopamine system readily reinforces behavior, little is known about the role of glutamate co-transmission in such reinforcement. By combining electrode recording and optogenetics, we found that stimulation of VTA dopamine neurons in vivo evoked fast excitatory responses in many VStr neurons of adult mice. Whereas conditional knockout of the gene encoding VGLUT2 in dopamine neurons largely eliminated fast excitatory responses, it had little effect on the acquisition of conditioned responses reinforced by dopamine neuron activation. Therefore, glutamate co-transmission appears dispensable for acquisition of conditioned responding reinforced by DA neuron activation.
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