期刊
CELL REPORTS
卷 19, 期 8, 页码 1723-1738出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.05.006
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资金
- NCI [5P01CA013106-Project 3, 2P30CA45508]
- NIGMS [42694]
- Intramural Research Program of the NIH
- National Library of Medicine
- Department of Defense Prostate Cancer Research Program postdoctoral fellowship [W81XWH-10-1-0190]
- National Cancer Center postdoctoral fellowship
The MALAT1 (Metastasis-Associated Lung Adenocarcinoma Transcript 1) gene encodes a noncoding RNA that is processed into a long nuclear retained transcript (MALAT1) and a small cytoplasmic tRNA-like transcript (mascRNA). Using an RNA sequence-and structure-based covariance model, we identified more than 130 genomic loci in vertebrate genomes containing the MALAT1 30 end triple-helix structure and its immediate downstream tRNA-like structure, including 44 in the green lizard Anolis carolinensis. Structural and computational analyses revealed a co-occurrence of components of the 30 end module. MALAT1-like genes in Anolis carolinensis are highly expressed in adult testis, thus we named them testis-abundant long noncoding RNAs (tancRNAs). MALAT1-like loci also produce multiple small RNA species, including PIWI-interacting RNAs (piRNAs), from the antisense strand. The 30 ends of tancRNAs serve as potential targets for the PIWI-piRNA complex. Thus, we have identified an evolutionarily conserved class of long noncoding RNAs (lncRNAs) with similar structural constraints, post-transcriptional processing, and subcellular localization and a distinct function in spermatocytes.
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