期刊
CELL REPORTS
卷 21, 期 12, 页码 3624-3636出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.11.097
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类别
资金
- Micromon Sequencing platform at Monash University
- National Health and Medical Research Council of Australia [5671222, APP1003131]
- NHMRC
Infection triggers large-scale changes in the phenotype and function of T cells that are critical for immune clearance, yet the gene regulatory mechanisms that control these changes are largely unknown. Using ChIP-seq for specific histone post-translational modifications (PTMs), we mapped the dynamics of similar to 25,000 putative CD8(+) T cell transcriptional enhancers (TEs) differentially utilized during virus-specific T cell differentiation. Interestingly, we identified a subset of dynamically regulated TEs that exhibited acquisition of a non-canonical (H3K4me3(+)) chromatin signature upon differentiation. This unique TE subset exhibited characteristics of poised enhancers in the naive CD8(+) T cell subset and demonstrated enrichment for transcription factor binding motifs known to be important for virus-specific CD8(+) T cell differentiation. These data provide insights into the establishment and maintenance of the gene transcription profiles that define each stage of virus-specific T cell differentiation.
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