期刊
CELL REPORTS
卷 20, 期 8, 页码 1755-1764出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.08.007
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资金
- Chilean FONDECYT Program CONICYT [1161787, 1141015]
- Direccion de Investigacion y Desarrollo-Universidad Austral de Chile (DID-UACh)
- Paracelsus Medical University [L-12/01/001-RIV]
- Stand-Alone Grant [E-12/15/077-RIT]
- European Union [HEALTH-F2-2011-278850, HEALTH-F2-2011-279288, FP7-REGPOT-316120]
- Austrian Science Fund FWF Special Research Program (SFB) [F4413-B23]
- State Government of Salzburg, Austria (Stiftungsprofessur) [20204-WISS/80/199-2014]
- Wellcome Trust [203151/Z/16/Z]
- MRC
- UK Multiple Sclerosis Society [941/11]
- David and Isobel Walker Trust
- Investissements d'avenir'' IHU-A-ICM and Obra Social La Caixa
- Swedish Science Council [2015-00550]
- Swedish Cancer Foundation [15 0735]
- Knut and Alice Wallenberg Foundation [2015.0030]
- European Research Council [AdG 294556 BBBARRIER]
- Leducq Foundation (Sphingonet) [14CVD02]
- National Health & Medical Research Council of Australia [628928]
- Swiss National Science Foundation [31003A_159514/1]
- Synapsis Foundation
- Medical Research Council [MC_PC_12009] Funding Source: researchfish
- Swedish Research Council [2015-00550] Funding Source: Swedish Research Council
- Swiss National Science Foundation (SNF) [31003A_159514] Funding Source: Swiss National Science Foundation (SNF)
The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfb(ret/ret) mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded to completion. PC-conditioned medium accelerated and enhanced OPC differentiation in vitro and increased the rate of remyelination in an ex vivo cerebellar slice model of demyelination. We identified Lama2 as a PC-derived factor that promotes OPC differentiation. Thus, the functional role of PCs is not restricted to vascular homeostasis but includes the modulation of adult CNS progenitor cells involved in regeneration.
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