期刊
CELL REPORTS
卷 20, 期 3, 页码 757-770出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.06.079
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资金
- CONICYT Becas-Chile
- Department of Health via National Institute for Health Research Comprehensive Biomedical Research Centre
- King's College London and King's College Hospital NHS Foundation Trust
- British Heart Foundation (BHF) [RG/13/12/30395]
- European Union 7th Framework Programme (EU FP7)
- Cancer Research UK/NIHR in England
- DoH in Scotland
- Wales and Northern Ireland Experimental Cancer Medicine Centre [C10355/A15587]
- Medical Research Council [MR/L023091/1]
- Wellcome Trust [101159/Z/13/Z] Funding Source: Wellcome Trust
- MRC [MR/L022699/1, MC_PC_14105, MR/L023091/1] Funding Source: UKRI
- British Heart Foundation [RG/13/12/30395] Funding Source: researchfish
- Crohn's and Colitis UK [M15-1] Funding Source: researchfish
- Medical Research Council [MR/L023091/1, MR/J006742/1, MR/L022699/1, MC_PC_14105] Funding Source: researchfish
- Wellcome Trust [101159/Z/13/Z] Funding Source: researchfish
Regulatory T cells (Tregs) play a pivotal role in maintaining immunological tolerance, but they can also play a detrimental role by preventing antitumor responses. Here, we characterized T helper (Th)-like Treg subsets to further delineate their biological function and tissue distribution, focusing on their possible contribution to disease states. RNA sequencing and functional assays revealed that Th2-like Tregs displayed higher viability and autocrine interleukin-2 (IL-2)-mediated activation than other subsets. Th2-like Tregs were preferentially found in tissues rather than circulation and exhibited the highest migratory capacity toward chemokines enriched at tumor sites. These cellular responses led us to hypothesize that this subset could play a role in maintaining a tumorigenic environment. Concurrently, Th2-like Tregs were enriched specifically in malignant tissues from patients with melanoma and colorectal cancer compared to healthy tissue. Overall, our results suggest that Th2-like Tregs may contribute to a tumorigenic environment due to their increased cell survival, higher migratory capacity, and selective T-effector suppressive ability.
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