期刊
CELL REPORTS
卷 20, 期 1, 页码 211-223出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.06.031
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资金
- Spanish MINECO [BFU2015-65372, BFU2013-48988-C2-01, CSD-2007-00008]
- Junta de Andalucia Proyecto de Excelencia [P09-CVI-5058]
- European Regional Development Fund (FEDER)
- UK Medical Research Council [G1100312/1]
- Cambridge Herchel Smith Foundation fellowship
- Medical Research Council [G1100312] Funding Source: researchfish
- MRC [G1100312] Funding Source: UKRI
Basement membranes (BMs) are specialized extracellular matrices required for tissue organization and organ formation. We study the role of laminin and its integrin receptor in the regulation of tissue migration during Drosophila oogenesis. Egg production in Drosophila involves the collective migration of follicle cells (FCs) over the BM to shape the mature egg. We show that laminin content in the BM increases with time, whereas integrin amounts in FCs do not vary significantly. Manipulation of integrin and laminin levels reveals that a dynamic balance of integrin-laminin amounts determines the onset and speed of FC migration. Thus, the interplay of ligand-receptor levels regulates tissue migration in vivo. Laminin depletion also affects the ultrastructure and biophysical properties of the BM and results in anterior-posterior misorientation of developing follicles. Laminin emerges as a key player in the regulation of collective cell migration, tissue stiffness, and the organization of anterior-posterior polarity in Drosophila.
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