期刊
CELL REPORTS
卷 19, 期 7, 页码 1431-1443出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.04.068
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资金
- Foundation against Cancer, a foundation of public interest [2014-214]
- Fund for Scientific Research (FWO) [G.0187.13N]
- Interuniversity Attraction Pole (IUAP) grant T-Time from the Belspo Agency [P7/39]
- BOF of Ghent University [BOF11/GOA/005]
- Institute for the Promotion of Innovation through Science and Technology Flanders (IWT-Vlaanderen)
- FWO [12N4515N, 1831317N]
- ERC Starting Grant [311377]
- Deutsche Forschungsgemeinschaft [DI 764/3, DI 764/9]
- Max-Planck-Society (IMPRS MCB, Freiburg)
- German Research Foundation [DFG SPP1937 DU112/5-1, SFB 854TP25N]
- European Research Council (ERC) [311377] Funding Source: European Research Council (ERC)
The Ly49E receptor is preferentially expressed on murine innate-like lymphocytes, such as epidermal V gamma 3 T cells, intestinal intraepithelial CD8 alpha alpha(+) T lymphocytes, and CD49a(+) liver natural killer (NK) cells. As the latter have recently been shown to be distinct from conventional NK cells and have innate lymphoid cell type 1 (ILC1) properties, we investigated Ly49E expression on intestinal ILC populations. Here, we show that Ly49E expression is very low on known ILC populations, but it can be used to define a previously unrecognized intraepithelial innate lymphoid population. This Ly49E-positive population is negative for NKp46 and CD8 alpha alpha, expresses CD49a and CD103, and requires T-bet expression and IL-15 signaling for differentiation and/or survival. Transcriptome analysis reveals a group 1 ILC gene profile, different from NK cells, iCD8 alpha cells, and intraepithelial ILC1. Importantly, NKp46(-)CD8 alpha alpha(-)Ly49E(+) cells produce interferon (IFN)-gamma, suggesting that this previously unrecognized population may contribute to Th1-mediated immunity.
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