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BLOOD REVIEWS (2017)
Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells
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NUCLEIC ACIDS RESEARCH (2016)
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BIOCHEMICAL JOURNAL (2016)
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CELLULAR AND MOLECULAR LIFE SCIENCES (2016)
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EMBO JOURNAL (2016)
Noncanonical views of homology-directed DNA repair
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GENES & DEVELOPMENT (2016)
Biallelic inactivation of REV7 is associated with Fanconi anemia
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JOURNAL OF CLINICAL INVESTIGATION (2016)
Complementation of hypersensitivity to DNA interstrand crosslinking agents demonstrates that XRCC2 is a Fanconi anaemia gene
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JOURNAL OF MEDICAL GENETICS (2016)
FANCD2 Facilitates Replication through Common Fragile Sites
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MOLECULAR CELL (2016)
Aldehydes with high and low toxicities inactivate cells by damaging distinct cellular targets
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MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2016)
The Fanconi anaemia pathway: newyplayers and new functions
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
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PHARMACOLOGY & THERAPEUTICS (2016)
Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability
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SCIENCE (2016)
p53 downregulates the Fanconi anaemia DNA repair pathway
Sara Jaber et al.
NATURE COMMUNICATIONS (2016)
FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair
Zeina Kais et al.
CELL REPORTS (2016)
Mutations in the Gene Encoding the E2 Conjugating Enzyme UBE2T Cause Fanconi Anemia
Asuka Hira et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2015)
DNA Damage in Cancer Therapeutics: A Boon or a Curse?
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CANCER RESEARCH (2015)
What is the DNA repair defect underlying Fanconi anemia?
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CURRENT OPINION IN CELL BIOLOGY (2015)
Fanconi anemia: a model disease for studies on human genetics and advanced therapeutics
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CURRENT OPINION IN GENETICS & DEVELOPMENT (2015)
Preventing replication fork collapse to maintain genome integrity
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DNA REPAIR (2015)
Regulation of the Rev1-pol ζ complex during bypass of a DNA interstrand cross-link
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EMBO JOURNAL (2015)
AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia
Elizabeth L. Virts et al.
HUMAN MOLECULAR GENETICS (2015)
The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription
Rebekka A. Schwab et al.
MOLECULAR CELL (2015)
Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations
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MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2015)
DNA interstrand cross-link repair requires replication-fork convergence
Jieqiong Zhang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Fanconi anemia (FA) and crosslinker sensitivity: Re-appraising the origins of FA definition
Giovanni Pagano et al.
PEDIATRIC BLOOD & CANCER (2015)
DNA interstrand cross-link repair requires replication-fork convergence
Jieqiong Zhang et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia
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CELL REPORTS (2015)
The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
Mara L. Garcia-Rubio et al.
PLOS GENETICS (2015)
DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining
Sean M. Howard et al.
PLOS GENETICS (2015)
Biallelic Mutations in BRCA1 Cause a New Fanconi Anemia Subtype
Sarah L. Sawyer et al.
CANCER DISCOVERY (2015)
Update of the human and mouse Fanconi anemia genes
Hongbin Dong et al.
HUMAN GENOMICS (2015)
TNF-α signaling in Fanconi anemia
Wei Du et al.
BLOOD CELLS MOLECULES AND DISEASES (2014)
The Fanconi anemia ID2 complex: Dueling saxes at the crossroads
Rebecca A. Boisvert et al.
CELL CYCLE (2014)
Mechanism and regulation of incisions during DNA interstrand cross-link repair
Jieqiong Zhang et al.
DNA REPAIR (2014)
A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression
Konstantina Skourti-Stathaki et al.
GENES & DEVELOPMENT (2014)
Proteomic analysis reveals a FANCA-modulated neddylation pathway involved in CXCR5 membrane targeting and cell mobility
Xavier Renaudin et al.
JOURNAL OF CELL SCIENCE (2014)
Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells
Thuy Vy Nguyen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
Therapeutic Melting Pot of Never in Mitosis Gene A Related Kinase 2 (Nek2): A Perspective on Nek2 as an Oncology Target and Recent Advancements in Nek2 Small Molecule Inhibition
Brendan Frett et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
BRCA1 Promotes Unloading of the CMG Helicase from a Stalled DNA Replication Fork
David T. Long et al.
MOLECULAR CELL (2014)
Mouse SLX4 Is a Tumor Suppressor that Stimulates the Activity of the Nuclease XPF-ERCC1 in DNA Crosslink Repair
Michael R. G. Hodskinson et al.
MOLECULAR CELL (2014)
R-loops induce repressive chromatin marks over mammalian gene terminators
Konstantina Skourti-Stathaki et al.
NATURE (2014)
Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein
Anaid Benitez et al.
NUCLEIC ACIDS RESEARCH (2014)
Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair
Meghan Larin et al.
NUCLEIC ACIDS RESEARCH (2014)
Evidence of mitochondrial dysfunction and impaired ROS detoxifying machinery in Fanconi Anemia cells
U. Kumari et al.
ONCOGENE (2014)
FANCD2 and CtIP Cooperate to Repair DNA Interstrand Crosslinks
Olga Murina et al.
CELL REPORTS (2014)
Modularized Functions of the Fanconi Anemia Core Complex
Yaling Huang et al.
CELL REPORTS (2014)
Coregulation of FANCA and BRCA1 in human cells
Anneke Haitjema et al.
SPRINGERPLUS (2014)
Mutations in ERCC4, Encoding the DNA-Repair Endonuclease XPF, Cause Fanconi Anemia
Massimo Bogliolo et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2013)
Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4
Yonghwan Kim et al.
BLOOD (2013)
The detection and implication of genome instability in cancer
Larissa Pikor et al.
CANCER AND METASTASIS REVIEWS (2013)
PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells
Laurence Booth et al.
CANCER BIOLOGY & THERAPY (2013)
Fanconi anemia complementation group A (FANCA) localizes to centrosomes and functions in the maintenance of centrosome integrity
Sunshin Kim et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)
Fanconi anemia signaling network regulates the spindle assembly checkpoint
Grzegorz Nalepa et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
Molly C. Kottemann et al.
NATURE (2013)
Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips
Nikita Gudimchuk et al.
NATURE CELL BIOLOGY (2013)
MUS81 promotes common fragile site expression
Songmin Ying et al.
NATURE CELL BIOLOGY (2013)
Human Fanconi Anemia Complementation Group A Protein Stimulates the 5′ Flap Endonuclease Activity of FEN1
Liangyue Qian et al.
PLOS ONE (2013)
Biosensing Approaches for Rapid Genotoxicity and Cytotoxicity Assays upon Nanomaterial Exposure
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SMALL (2013)
Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair
Cheryl Clauson et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Damaged mitochondria and overproduction of ROS in Fanconi anemia cells
Alex Lyakhovich
RARE DISEASES (2013)
Oxidative stress in Fanconi anaemia: from cells and molecules towards prospects in clinical management
Giovanni Pagano et al.
BIOLOGICAL CHEMISTRY (2012)
The FA pathway counteracts oxidative stress through selective protection of antioxidant defense gene promoters
Wei Du et al.
BLOOD (2012)
FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway
Abdullah Mahmood Ali et al.
BLOOD (2012)
Human MUS81 complexes stimulate flap endonuclease 1
Yong-Keol Shin et al.
FEBS JOURNAL (2012)
Fanconi Anemia Complementation Group A (FANCA) Protein Has Intrinsic Affinity for Nucleic Acids with Preference for Single-stranded Forms
Fenghua Yuan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Multiple DNA Binding Domains Mediate the Function of the ERCC1-XPF Protein in Nucleotide Excision Repair
Yan Su et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
R Loops: From Transcription Byproducts to Threats to Genome Stability
Andres Aguilera et al.
MOLECULAR CELL (2012)
FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair
Weibin Zhou et al.
NATURE GENETICS (2012)
Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome
Kelly A. Hoadley et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
The complex basis underlying common fragile site instability in cancer
Efrat Ozeri-Galai et al.
TRENDS IN GENETICS (2012)
Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions
Samuel Quentin et al.
BLOOD (2011)
Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair
Blanka Sengerova et al.
CELL CYCLE (2011)
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair
Anderson T. Wang et al.
GENES & DEVELOPMENT (2011)
DNA damage induced by endogenous aldehydes: Current state of knowledge
Georgia-Persephoni Voulgaridou et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2011)
Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice
Frederic Langevin et al.
NATURE (2011)
Functional regulation of FEN1 nuclease and its link to cancer
Li Zheng et al.
NUCLEIC ACIDS RESEARCH (2011)
Direct Inhibition of TNF-α Promoter Activity by Fanconi Anemia Protein FANCD2
Nobuko Matsushita et al.
PLOS ONE (2011)
PARP inhibitors: its role in treatment of cancer
Alice Chen
Chinese Journal of Cancer (2011)
DNA interstrand crosslink repair and cancer
Andrew J. Deans et al.
NATURE REVIEWS CANCER (2011)
Knockdown of μ-Calpain in Fanconi Anemia, FA-A, Cells by siRNA Restores αII Spectrin Levels and Corrects Chromosomal Instability and Defective DNA Interstrand Cross-Link Repair
Pan Zhang et al.
BIOCHEMISTRY (2010)
Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2
Craig MacKay et al.
CELL (2010)
Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents
Katja Kratz et al.
CELL (2010)
Human KIAA1018/FAN1 localizes to stalled replication forks via its ubiquitin-binding domain
Robert D. Shereda et al.
CELL CYCLE (2010)
The role of FAN1 nuclease in the Fanconi anemia pathway
Maria Castella et al.
CELL CYCLE (2010)
Mechanisms of Chromosomal Instability
Sarah L. Thompson et al.
CURRENT BIOLOGY (2010)
A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair
Agata Smogorzewska et al.
MOLECULAR CELL (2010)
Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia
Adele Adamo et al.
MOLECULAR CELL (2010)
Mutation of the RAD51C gene in a Fanconi anemia-like disorder
Fiona Vaz et al.
NATURE GENETICS (2010)
Genomic instability - an evolving hallmark of cancer
Simona Negrini et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents
Kazunori Yoshikiyo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair
Ting Liu et al.
SCIENCE (2010)
Identification of FANCA as a protein interacting with centromere-associated protein E
Jian Du et al.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2009)
How the Fanconi Anemia Pathway Guards the Genome
George-Lucian Moldovan et al.
ANNUAL REVIEW OF GENETICS (2009)
Knockdown of αII spectrin in normal human cells by siRNA leads to chromosomal instability and decreased DNA interstrand cross-link repair
Laura W. McMahon et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
The SH3 Domain of αII Spectrin Is a Target for the Fanconi Anemia Protein, FANCG
Joel A. Lefferts et al.
BIOCHEMISTRY (2009)
ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function
Natalie B. Collins et al.
BLOOD (2009)
The Fanconi Anemia Core Complex Acts as a Transcriptional Co-regulator in Hairy Enhancer of Split 1 Signaling
Cedric S. Tremblay et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
XPF-ERCC1 Participates in the Fanconi Anemia Pathway of Cross-Link Repair
Nikhil Bhagwat et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
FANCM Connects the Genome Instability Disorders Bloom's Syndrome and Fanconi Anemia
Andrew J. Deans et al.
MOLECULAR CELL (2009)
Fanconi anemia and its diagnosis
Arleen D. Auerbach
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2009)
Chromosome congression: on the bi-orient express
Emily A. Foley et al.
NATURE CELL BIOLOGY (2009)
The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities
Valeria Naim et al.
NATURE CELL BIOLOGY (2009)
Mechanism of replication-coupled DNA interstrand crosslink repair
Markus Raeschle et al.
CELL (2008)
Fanconi anemia proteins stabilize replication forks
Lily Chien Wang et al.
DNA REPAIR (2008)
Self-promoted DNA interstrand cross-link formation by an abasic site
Jonathan T. Sczepanski et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
An oncogene-induced DNA damage model for cancer development
Thanos D. Halazonetis et al.
SCIENCE (2008)
Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair
Nicole Bennardo et al.
PLOS GENETICS (2008)
Processing of a psoralen DNA interstrand cross-link by XPF-ERCC1 complex in vitro
Laura A. Fisher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells
Ali Z. Al-Minawi et al.
NUCLEIC ACIDS RESEARCH (2008)
TNF-α induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells
June Li et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks
Katsuhiro Hanada et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges
Kok-Lung Chan et al.
EMBO JOURNAL (2007)
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair
Agata Smogorzewska et al.
CELL (2007)
The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks
Katsuhiro Hanada et al.
EMBO JOURNAL (2006)
Evidence for subcomplexes in the Fanconi anemia pathway
Annette L. Medhurst et al.
BLOOD (2006)
Free radicals, metals and antioxidants in oxidative stress-induced cancer
M Valko et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2006)
Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks
A Sobeck et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells
YG Yang et al.
CARCINOGENESIS (2005)
Modulation of DNA end joining by nuclear proteins
L Liang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Identification of multiple nuclear export sequences in Fanconi anemia group A protein that contribute to CRM1-dependent nuclear export
M Ferrer et al.
HUMAN MOLECULAR GENETICS (2005)
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
J Bartkova et al.
NATURE (2005)
The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability
NG Howlett et al.
HUMAN MOLECULAR GENETICS (2005)
Oxidant hypersensitivity of Fanconi anemia type C-deficient cells is dependent on a redox-regulated apoptotic pathway
MR Saadatzadeh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Oxidative stress/damage induces multimerization and interaction of Fanconi anemia proteins
SJ Park et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
INK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
JJ Ventura et al.
GENES & DEVELOPMENT (2004)
Interstrand crosslink-induced radials form between non-homologous chromosomes, but are absent in sex chromosomes
AEH Newell et al.
DNA REPAIR (2004)
Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia
MW Lensch et al.
BLOOD (2003)
Oxidative DNA damage: mechanisms, mutation, and disease
MS Cooke et al.
FASEB JOURNAL (2003)
FANCF methylation contributes to chemoselectivity in ovarian cancer
OI Olopade et al.
CANCER CELL (2003)
A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome
AR Meetei et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Nonerythroid all spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links
D Sridharan et al.
JOURNAL OF CELL SCIENCE (2003)
High incidence of head and neck squamous cell carcinoma in patients with Fanconi Anemia
DI Kutler et al.
ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY (2003)
Bi-allelic silencing of the Fanconi anaemia gene FANCF in acute myeloid leukaemia
M Tischkowitz et al.
BRITISH JOURNAL OF HAEMATOLOGY (2003)
Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants
D Adachi et al.
HUMAN MOLECULAR GENETICS (2002)
BRCA1 interacts directly with the Fanconi anemia protein FANCA
A Folias et al.
HUMAN MOLECULAR GENETICS (2002)
The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage
M Futaki et al.
CARCINOGENESIS (2002)
Human α spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links
LW McMahon et al.
BIOCHEMISTRY (2001)
Hydrogen peroxide: effects on DNA, chromosomes, cell cycle and apoptosis induction in Fanconi's anemia cell lines
A Zunino et al.
MUTAGENESIS (2001)
Role of ERCC1 in removal of long non-homologous tails during targeted homologous recombination
GR Adair et al.
EMBO JOURNAL (2000)
Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
D Gisselsson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Fanconi anemia, complementation group A, cells are defective in ability to produce incisions at sites of psoralen interstrand cross-links
KR Kumaresan et al.
CARCINOGENESIS (2000)