期刊
BRAIN AND LANGUAGE
卷 168, 期 -, 页码 37-46出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bandl.2017.01.005
关键词
Parkinson's disease; Mild cognitive impairment; Picture naming; Action verbs; Manipulable nouns; Motor semantics
资金
- Comite para el Desarrollo de la Investigacion (CODI), University of Antioquia [2014-768]
- CONICET
- CONICYT/FONDECYT [Regular 1130920]
- FONDAP [15150012]
- INECO Foundation
- COLCIENCIAS under grants from Convocatoria 528 para estudios de doctorado en Colombia, generation del bicentenario
- FONCyT-PICT [2012-0412, 2012-1309]
Parkinson's disease (PD) patients show marked impairments in processing action verbs, and to a lesser extent, concrete (specially, manipulable) nouns. However, it is still unclear to what extent deficits in each of these categories are influenced by more general cognitive dysfunctions, and whether they are modulated by the words' implied motility. To examine these issues, we evaluated 49 non-demented PD patients and 49 healthy volunteers in an oral production task. The patients were divided into two groups depending on the presence or absence of mild cognitive impairment (PD-MCI and PD-nMCI, respectively). Participants named pictures of actions varying in motion content (low and high) and of objects varying in manipulability (low and high). The PD-MCI group showed deficits across all four categories. However, PD-nMCI patients exhibited a selective difficulty for high-motion action verbs. This finding corroborates and refines previous results suggesting that disturbances of action-related lexico-semantic information in PD constitute a sui generis alteration manifested early in the course of the disease's physiopathology. Moreover, it suggests that the grounding of action verbs on motor circuits could depend on finegrained intracategorical semantic distinctions. (C) 2017 Elsevier Inc. All rights reserved.
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