期刊
ACTA PAEDIATRICA
卷 106, 期 5, 页码 796-800出版社
WILEY
DOI: 10.1111/apa.13773
关键词
Epidemiology; Incidence rate; Kawasaki disease; Mucocutaneous lymph node syndrome; Recurrence
类别
资金
- Japanese Kawasaki Disease Research Centre
AimSince Kawasaki disease (KD) was first reported in 1967, its aetiology has been intensively investigated, but remains unclear. We investigated the incidence of recurrent KD in Japan in 2003-2012, compared with previous data from our team, and assessed the potential risk factors for disease recurrence. MethodsData from nationwide KD surveys were retrospectively analysed and 81310 patients were observed. Incidence rates were compared between different years. ResultsThe incidence rates for recurrent KD were 3.89 per 1000 person-years (January 2003 to December 2012), 4.95 (July 2003 to December 2010), 6.48 (January 2003 to December 2006) and 6.51 (January 2007 to December 2010). These rates were almost consistent with our previous data, which started in the 1980s. The incidence rate for recurrence was statistically higher among males, patients under the age of three years and those who received intravenous immunoglobulin or steroid therapy at the initial episode. The presence of cardiac sequelae during the initial episode did not affect the recurrence incidence. ConclusionAlthough the incidence of KD has increased, the incidence of recurrent KD has remained largely unchanged over the past 30years. Risk factors for recurrence included male sex, young age and initial resistance to immunoglobulin therapy.
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