期刊
CLINICAL CANCER RESEARCH
卷 23, 期 8, 页码 1891-1897出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-15-2240
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资金
- Cancer Center Support Grant [2 P30 CA060553-19]
- Woman's Board of Northwestern Memorial Hospital
- NCI SPORE in Pancreatic Cancer grant [CA102701]
Glycogen synthase kinase-3 beta (GSK-3 beta), a serine/threonine protein kinase, is a complex regulator of numerous cellular functions. GSK-3 beta is a unique kinase which is constitutively active in resting and nonstimulated cells. GSK-3 beta has been implicated in a wide range of diseases including neurodegeneration, inflammation and fibrosis, noninsulin-dependent diabetes mellitus, and cancer. It is a regulator of NF-kappa B-mediated survival of cancer cells, which provided a rationale for the development of GSK-3 inhibitors targeting malignant tumors. Recent studies, many of them reported over the past decade, have identified GSK-3 beta as a potential therapeutic target in more than 15 different types of cancer. Whereas only active GSK-3 beta is expressed in cancer cell nucleus, aberrant nuclear accumulation of GSK-3 beta has been identified as a hallmark of cancer cells in malignant tumors of different origin. This review focuses on the preclinical and clinical development of GSK-3 inhibitors and the potential therapeutic impact of targeting GSK-3 beta in human cancer. (C) 2017 AACR.
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