4.8 Article

An Immune Atlas of Clear Cell Renal Cell Carcinoma

期刊

CELL
卷 169, 期 4, 页码 736-749

出版社

CELL PRESS
DOI: 10.1016/j.cell.2017.04.016

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资金

  1. SNSF
  2. SystemsX Transfer Project Friends and Foes
  3. SystemsX MetastasiX grant
  4. European Research Council (ERC) under the European Union/ERC [336921]
  5. Roche
  6. EMBO - European Commission [ALTF 970-2014, GA-2013-609409]
  7. RACP CSL Fellowship
  8. CIHR/KCC SHOPP Fellowship
  9. NHMRC [628939]
  10. NIH [DP1-HD084071, R01CA164729]
  11. SNSF [31003A_152851]
  12. Zurich Cancer League grant
  13. Stiftung fur Forschung in der Onkologie grant
  14. University Research Priority Project Translational Cancer Research grant
  15. MSK Cancer Center [P30 CA008748]
  16. F. Hoffmann-La Roche AG
  17. Swiss National Science Foundation (SNF) [31003A_152851] Funding Source: Swiss National Science Foundation (SNF)
  18. European Research Council (ERC) [336921] Funding Source: European Research Council (ERC)

向作者/读者索取更多资源

Immune cells in the tumor microenvironment modulate cancer progression and are attractive therapeutic targets. Macrophages and T cells are key components of the microenvironment, yet their phenotypes and relationships in this ecosystem and to clinical outcomes are ill defined. We used mass cytometry with extensive antibody panels to perform in-depth immune profiling of samples from 73 clear cell renal cell carcinoma (ccRCC) patients and five healthy controls. In 3.5 million measured cells, we identified 17 tumor-associated macrophage phenotypes, 22 T cell phenotypes, and a distinct immune composition correlated with progression-free survival, thereby presenting an in-depth human atlas of the immune tumor microenvironment in this disease. This study revealed potential biomarkers and targets for immunotherapy development and validated tools that can be used for immune profiling of other tumor types.

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