期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 486, 期 3, 页码 726-731出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2017.03.106
关键词
PPAR gamma; miR-124; Inflammatory cytokines; Inflammation
资金
- PLA Medical Technology Young Fostering Foundation [13QNP114]
- Clinical Research Key Project of the Second Hospital Affiliated [2016YLC06]
Peroxisome proliferator-activated receptor gamma (PPAR gamma) and miR-124 have been reported to play important roles in regulation of inflammation. However, the underlying anti-inflammatory mechanisms remain not well understood. In the present study, we demonstrated that the expression level of PPAR gamma is positively correlated with that of miR-124 in patients with sepsis. Activation of PPAR gamma upregulates miR-124 and in turn inhibits miR-124 target gene. PPAR gamma bound directly to PPRE in the miR-124 promoter region, and enhanced the promoter transcriptional activity. PPAR gamma-induced miR-124 is involved in the suppression of pro-inflammatory cytokine in vitro and in vivo. These results suggest that PPAR gamma-induced miR-124 inhibits the production of pro-inflammatory cytokines is a novel PPAR gamma anti-inflammatory mechanism and also indicate that miR-124 may be a potential therapeutic target for the treatment of inflammatory diseases. (C) 2017 Published by Elsevier Inc.
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