期刊
CHEMICAL COMMUNICATIONS
卷 53, 期 37, 页码 5151-5154出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc01069a
关键词
-
资金
- National Nature Science Foundation of China [21232004, 21402117, 21620102003]
- Science and Technology Commission of Shanghai Municipality [14XD1402300, 15Z111220016]
Allylic alcohols and allylic amines were directly utilized in a Pd-catalyzed hydrogen-bond-activated allylic amination under mild reaction conditions in the absence of any additives. The cooperative action of a Pd-catalyst and a hydrogen-bonding solvent is most likely responsible for its high reactivity. The catalytic system is compatible with a variety of functional groups and can be used to prepare a wide range of linear allylic amines in good to excellent yields. Furthermore, this methodology can be easily applied to the one-step synthesis of two drugs, cinnarizine and naftifine, on a gram scale.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据