期刊
DEVELOPMENTAL CELL
卷 41, 期 3, 页码 228-241出版社
CELL PRESS
DOI: 10.1016/j.devcel.2017.04.001
关键词
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资金
- NCI NIH HHS [R01 CA178974] Funding Source: Medline
The Notch signaling pathway relies on a proteolytic cascade to release its transcriptionally active intracellular domain, on force to unfold a protective domain and permit proteolysis, on extracellular domain glycosylation to tune the forces exerted by endocytosed ligands, and on a motley crew of nuclear proteins, chromatin modifiers, ubiquitin ligases, and a few kinases to regulate activity and half-life. Herein we provide a review of recent molecular insights into how Notch signals are triggered and how cell shape affects these events, and we use the new insights to illuminate a few perplexing observations.
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