期刊
ANTIVIRAL RESEARCH
卷 141, 期 -, 页码 165-173出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.antiviral.2017.02.018
关键词
Umifenovir; Coxsackie B4; Viral myocarditis; IL-10; P38 MAPK; MAPK-activated protein kinase 2
资金
- Jilin Provincial Science & Technology Department [20070412]
Coxsackie virus cannot be completely eliminated due to restrictive replication and impaired immune response, thus causing persistent infection. IL-10 plays a decisive role in the course of persistent viral infection. Umifenovir is a broad-spectrum antiviral drug, with certain treatment effects on Coxsackie virus infection. Previously, we showed that in addition to inhibiting Coxsackie B4 (CVB4) infection, Umifenovir also down-regulates IL-10 induced by persistent CVB4 virus infection in vitro and in vivo. Here, BALB/c mouse spleen cells infected with CVB4 were used as a model to explore the mechanism by which Umifenovir affects IL-10 expression. We found that subcellular localization of p38 and MAPKactivated protein kinase 2 (MK2) played a very important role in IL-10 secretion, and Umifenovir significantly prevented p38-MK2 complex from exiting the cell nucleus. This in turn blocked the biological functions of the latter pathway, and inhibited the high expression of IL-10 induced by CVB4. These findings suggest that Umifenovir is a potential anti-CVB4 drug; most importantly, Umifenovir could be used to treat IL-10 induced persistent viral infection. (C) 2017 Elsevier B.V. All rights reserved.
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