期刊
DERMATOLOGIC CLINICS
卷 35, 期 2, 页码 205-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.det.2016.11.015
关键词
Vitiligo; Repigmentation; Melanocyte stem cell; Bulge; Hair follicle; Proliferation; Migration; Differentiation
类别
资金
- American Skin Association Research Scholar Award in Vitiligo/Pigment Cell Disorders
Repigmentation in vitiligo is the process that replaces, in the epidermal basal layer of vitiligo skin, the mature melanocytes that have been killed by cytotoxic T cells specific for melanocyte antigens. It consists of mobilization of melanocyte precursors in the hair follicle bulge and infundibulum to proliferate, migrate, and differentiate into mature melanocytes, moving from the hair follicle bulge to the interfollicular epidermis. The most common clinical presentation of repigmentation in vitiligo is the perifollicular pattern. The most potent stimulus for repigmentation is the UV light.
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