4.2 Article

Repigmentation through Melanocyte Regeneration in Vitiligo

期刊

DERMATOLOGIC CLINICS
卷 35, 期 2, 页码 205-+

出版社

W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.det.2016.11.015

关键词

Vitiligo; Repigmentation; Melanocyte stem cell; Bulge; Hair follicle; Proliferation; Migration; Differentiation

资金

  1. American Skin Association Research Scholar Award in Vitiligo/Pigment Cell Disorders

向作者/读者索取更多资源

Repigmentation in vitiligo is the process that replaces, in the epidermal basal layer of vitiligo skin, the mature melanocytes that have been killed by cytotoxic T cells specific for melanocyte antigens. It consists of mobilization of melanocyte precursors in the hair follicle bulge and infundibulum to proliferate, migrate, and differentiate into mature melanocytes, moving from the hair follicle bulge to the interfollicular epidermis. The most common clinical presentation of repigmentation in vitiligo is the perifollicular pattern. The most potent stimulus for repigmentation is the UV light.

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