期刊
DERMATOLOGIC CLINICS
卷 35, 期 2, 页码 245-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.det.2016.11.013
关键词
Vitiligo; Autoimmunity; Gene; Genomewide association study; Genetic linkage; Genetic epidemiology
类别
资金
- NIAMS NIH HHS [R01 AR065951, R01 AR045584, R01 AR056292] Funding Source: Medline
Vitiligo reflects simultaneous contributions of multiple genetic risk factors and environmental triggers. Genomewide association studies have discovered approximately 50 genetic loci contributing to vitiligo risk. At many vitiligo susceptibility loci, the relevant genes and DNA sequence variants are identified. Many encode proteins involved in immune regulation, several play roles in cellular apoptosis, and others regulate functions of melanocytes. Although many of the specific biologic mechanisms need elucidation, it is clear that vitiligo is an autoimmune disease involving a complex relationship between immune system programming and function, aspects of the melanocyte autoimmune target, and dysregulation of the immune response.
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