期刊
CANCER BIOLOGY & THERAPY
卷 18, 期 3, 页码 152-157出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15384047.2017.1281498
关键词
Bone-marrow derived DCs; cell development; macrophages; microarray; miRNA
类别
资金
- National Institutes of Health [R01CA79892, R01CA90631, 5P30CA16056]
- Breast Cancer Research Grant from Susan Komen Foundation
There is increasing evidence showing specific roles of microRNA in cell differentiation and cancer progression. Here we examine miRNA profiles during maturation of monocytes and bone marrow-derived dendritic cells (BMDCs) in human and mouse, respectively. We have identified significant changes of various miRNA expression during monocyte and BMDC monocyte development via miRNA microarrays, confirmed by quantitative PCR. Increases in miR155 expression positively correlated with increasing maturity of monocyte and BMDC in both mouse and human microarrays, indicating its importance in development. We describe a requirement of miR155 for MHCII expression during GM-CSF-induced development and LPS-induced maturation of DCs, suggesting reduced immune function of DC when miR155 is absent. Our study suggests that miRNAs might have an important role in differentiation of myeloid cell such as dendritic cells and macrophages.
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