期刊
CELL HOST & MICROBE
卷 21, 期 5, 页码 592-+出版社
CELL PRESS
DOI: 10.1016/j.chom.2017.04.002
关键词
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资金
- US National Institutes of Health [RO1 AI42135, RO1 AI95706, UO1 AI124275, P30 CA008748]
- Tow Foundation
- Lucille Castori Center for Microbes, Inflammation and Cancer
- Gilliam pre-doctoral fellowship from Howard Hughes Medical Institute
Antibiotic-mediated microbiota destruction and the consequent loss of colonization resistance can result in intestinal domination with vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patients. Clearance of VRE remains a challenging goal that, if achieved, would reduce systemic VRE infections and patient-to-patient transmission. Although obligate anaerobic commensal bacteria have been associated with colonization resistance to VRE, the specific bacterial species involved remain undefined. Herein, we demonstrate that a precisely defined consortium of commensal bacteria containing the Clostridium-cluster XIVa species Blautia producta and Clostridium bolteae restores colonization resistance against VRE and clears VRE from the intestines of mice. While C. bolteae did not directly mediate VRE clearance, it enabled intestinal colonization with B. producta, which directly inhibited VRE growth. These findings suggest that therapeutic or prophylactic administration of defined bacterial consortia to individuals with compromised microbiota composition may reduce inter-patient transmission and intra-patient dissemination of highly antibiotic-resistant pathogens.
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