期刊
CARBOHYDRATE POLYMERS
卷 165, 期 -, 页码 294-303出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.02.039
关键词
Acacia-gum; Drug delivery; Wound dressing
资金
- UGC, New Delhi, India [F.17-40/08(SA-I)]
Keeping in view the importance of polysaccharide gums for wound care, in the present article, an attempt has been made to explore antioxidant nature of gum acacia in designing hydrogel wound dressing to improve its wound healing potential. These polymers were prepared by using acacia gumpolyvinylpyrollidone/carbopol and were characterized by C-13 NMR, FTIR, SEM, AFM, cryo-SEM, XRD, TGA, DSC and elemental analysis techniques. Some important biomaterial properties of wound dressings such as wound fluid absorption, haemo-compatibility, bioactive assessment, gaseous/water/microbial permeability, mechanical properties, bio-adhesion, drug release, and histology of wound healing were also determined. Hydrogel wound dressings were found non-haemolytic, antioxidant and mucoadhesive in nature. Release of drug occurred through non-Fickian diffusion mechanism and release profile best fitted in Higuchi model. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据