期刊
BRAIN PATHOLOGY
卷 27, 期 3, 页码 364-369出版社
WILEY
DOI: 10.1111/bpa.12501
关键词
craniopharyngioma; mouse model
资金
- Cancer Research UK [S_1731] Funding Source: researchfish
- Children with Cancer UK [15-190] Funding Source: researchfish
- Great Ormond Street Hospital Childrens Charity [W1055] Funding Source: researchfish
- Medical Research Council [MR/M000125/1] Funding Source: researchfish
- Medical Research Council [MR/M000125/1] Funding Source: Medline
- MRC [MR/M000125/1] Funding Source: UKRI
Adamantinomatous craniopharyngioma (ACP) is the commonest tumor of the sellar region in childhood. Two genetically engineered mouse models have been developed and are giving valuable insights into ACP biology. These models have identified novel pathways activated in tumors, revealed an important function of paracrine signalling and extended conventional theories about the role of organ-specific stem cells in tumorigenesis. In this review, we summarize these mouse models, what has been learnt, their limitations and open questions for future research. We then discussed how these mouse models may be used to test novel therapeutics against potentially targetable pathways recently identified in human ACP.
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