4.8 Article

Domino N-/C-Arylation via In Situ Generation of a Directing Group: Atom-Efficient Arylation Using Diaryliodonium Salts

期刊

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 19, 页码 5263-5266

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201701523

关键词

arylation; C-H activation; iodonium compounds; N-heterocycles

资金

  1. EPSRC
  2. Marie Curie actions (intra-European fellowship)
  3. EPSRC [EP/K013599/1] Funding Source: UKRI
  4. Biotechnology and Biological Sciences Research Council [1595377] Funding Source: researchfish
  5. Engineering and Physical Sciences Research Council [1237115, EP/K013599/1] Funding Source: researchfish

向作者/读者索取更多资源

Both aryl components of diaryliodonium salts can be used in a domino one-pot reaction via in situ generation of a directing group. A number of heterocycles undergo N-arylation which is followed by ruthenium-catalyzed C-arylation. Notably the reaction extends well to unsymmetrical diaryliodonium salts with a number of highly selective examples shown.

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