Immobilisation of catalytically active proline on H2N-MIL-101 (Al) accompanied with reversal in enantioselectivity

Proline-functionalized H2N-MIL-101(Al) was synthesized from L- or p-proline-terephthalic acid and used in the catalytic aldol reaction of p-nitrobenzaldehyde with acetone to achieve up to 95% conversion and an ee-value of 29% but in a reversal in enantioselectivity compared to the reaction under homogeneous L- or D-proline organocatalytic condition. (C) 2017 Elsevier B.V. All rights reserved.