期刊
ADVANCED MATERIALS
卷 29, 期 18, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201700244
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资金
- Singapore Ministry of Education [R143000627112, R143000642112]
- Singapore Institute for Neurotechnology [R175000121733]
- NUHS Clinician Research Grant [R175000133733]
- National Research Foundation, Prime Minister's Office, Singapore under its Competitive Research Program (CRP) [NRF-CRP15-2015-03]
- National Basic Research Program of China (973 Program) [2015CB932200]
- National Natural Science Foundation of China [61136003]
- Natural Science Foundation of Jiangsu Province [BE2015699]
- CAS/SAFEA International Partnership Program for Creative Research Teams
- Korea Health Promotion Institute [1710910-1] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Although multifunctional upconversion imaging probes have recently attracted considerable interest in biomedical research, there are currently few methods for stabilizing these luminescent nanoprobes with oligonucleotides in biological systems. Herein, a method to robustly disperse upconversion nanoprobes in physiological buffers based on rational design and synthesis of nanoconjugates comprising hairpin-DNA-modified gold nanoparticles is presented. This approach imparts the upconversion nanoprobes with excellent biocompatibility and circumvents the problem of particle agglomeration. By combining single-band anti-Stokes near-infrared emission and the photothermal effect mediated by the coupling of gold to upconversion nanoparticles, a simple, versatile nanoparticulate system for simultaneous deep-tissue imaging and drug molecule release in vivo is demonstrated.
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