期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 23, 期 27, 页码 6586-6595出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201700060
关键词
antitumor agents; drug delivery; lipids; nanoparticles; pH response
资金
- Program for New Century Excellent Talents in University [NCET-13-0720]
- National Hi-Technology Research and Development Program (863 Program) [2013AA032204]
- Fundamental Research Funds for the Central Universities [2412016KJ007, 2412016KJ020]
- Shenyang Technology Council [170483]
- Program for young and middle-aged teachers' development of Shenyang Pharmaceutical University
Herein, we report a facile strategy to prepare supported lipid-bilayer-coated polyacrylic acid/calcium phosphate nanoparticles (designated as PAA/CaP@SLB NPs) as a new dual pH-responsive drug-delivery platform for cancer chemotherapy. The synthesized PAA/CaP NPs exhibited both a high payload of doxorubicin (DOX) and dual pH-responsive drug-release properties. Additionally, the coated lipid bilayer had the ability to enhance the cellular uptake of PAA/CaP NPs without affecting the pH-responsive drug release. Moreover, the blank PAA/CaP@SLB NPs exhibited excellent biocompatibility and the DOX-loaded PAA/CaP@SLB NPs markedly increased the cellular accumulation of DOX and its cytotoxic effects on HepG-2 cells. Furthermore, when used to evaluate the in vivo therapeutic efficacy in mice with the hepatocarcinoma cell line (H-22), the DOX-loaded PAA/CaP@SLB NPs exhibited superior inhibition of tumor growth compared with the free DOX group. Thus, PAA/CaP@SLB NPs are a promising drug-delivery vehicle to increase the therapeutic efficacy of anticancer drugs.
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