期刊
BIOSENSORS & BIOELECTRONICS
卷 91, 期 -, 页码 523-537出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2017.01.011
关键词
Ratiometric; Electrochemical sensors; Biosensors; Dual-signal sensing; Switching
类别
资金
- National Natural Science Foundation of China [21475071, 21405086]
- Natural Science Foundation of Shandong [ZR2014BQ001, ZR2016BB37]
- Taishan Scholar Program of Shandong [ts201511027]
- Postdoctoral Applied Research Project of Qingdao [2015136]
Previously developed electrochemical biosensors with single-electric signal output are probably affected by intrinsic and extrinsic factors. In contrast, the ratiometric electrochemical biosensors (RECBSs) with dual electric signal outputs have an intrinsic built-in correction to the effects from system or background electric signals, and therefore exhibit a significant potential to improve the accuracy and sensitivity in electrochemical sensing applications. In this review, we systematically summarize the fabrication strategies, sensing modes and analytical applications of RECBSs. First, the different fabrication strategies of RECBSs were introduced, referring to the analytes-induced single- and dual-dependent electrochemical signal strategies for RECBSs. Second, the different sensing modes of RECBSs were illustrated, such as differential pulse voltammetry, square wave voltammetry, cyclic voltammetry, alternating current voltammetry, electrochemiluminescence, and so forth. Third, the analytical applications of RECBSs were discussed based on the types of target analytes. Finally, the forthcoming development and future prospects in the research field of RECBSs were also highlighted.
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