期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 153, 期 -, 页码 19-26出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2017.02.008
关键词
Dual drug release; Polymeric micelle; Hydrogel; Fluorescence observation
资金
- Grants-in-Aid for Scientific Research [16J07706] Funding Source: KAKEN
In the present study, we designed hydrogels for dual drug release: the hydrogels that covalently contained the polymeric micelles that possess different drug release properties. The hydrogels that were formed from polymeric micelles possessing a tightly packed (i.e., well-entangled) inner core exhibited a higher storage modulus than the hydrogels that were formed from the polymeric micelles possessing a loosely packed structure. Furthermore, we conducted release experiments and fluorescent observations to evaluate the profiles depicting the release of two compounds, rhodamine B and auramine O, from either polymeric micelles or hydrogels. According to our results, (1) hydrogels that covalently contains polymeric micelles that possess different drug release properties successfully exhibit the independent release behaviors of the two compounds and (2) fluorescence microscopy can greatly facilitate efforts to evaluate drug release properties of materials. (C) 2017 Elsevier B.V. All rights reserved.
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