期刊
CANCER RESEARCH
卷 77, 期 9, 页码 2534-2547出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-16-1887
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资金
- Chinese Ministry of Science and Technology [2012CB966800, 2013CB967402, 2013CB945600]
- National Natural Science Foundation of China (NSFC) [81630073, 81372189]
- State Key Laboratory of Oncogenes and Related Genes [90-16-03, 90-13-06]
- Shanghai Institutions of Higher Learning [QD2015002]
- Shanghai Rising-Star Program [17QA1402100]
- School of Medicine, Shanghai Jiao Tong University [16XJ11003]
- Ren Ji Hospital [RJZZ14-010]
- Science and Technology Commission of Shanghai Municipality [16JC1405700, 16140902100]
- KC Wong Foundation
- Special Research Foundation of State Key Laboratory of Medical Genomics
- Shanghai Eastern Hospital (Pudong) Stem Cell Research Base Fund
Cancer stem-like cells (CSC) drive cancer progression and recurrence. Self-renewal expansion of CSC is achieved through symmetric cell division, yet how external stimuli affect intracellular regulatory programs of CSC division modes and stemness remains obscure. Here, we report that the hTERThigh prostate cancer cells exhibit CSC properties, including a stem cell-associated gene expression signature, long-term tumor-propagating capacity and epithelial-to-mesenchymal transition. In promoting the self-renewal symmetric division of hTERThigh prostate cancer cells, WNT3a dramatically decreased the ratio of hTERThigh prostate cancer cells undergoing asymmetric division. Increased WNT/beta-catenin signal activation was also detected in hTERThigh prostate cancer cells. hTERT-mediated CSC properties were at least partially dependent on beta-catenin. These findings provide novel cellular and molecular mechanisms for the self-renewal of CSC orchestrated by tumor microenvironmental stimuli and intracellular signals. (C) 2017 AACR.
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