期刊
CHEMICAL COMMUNICATIONS
卷 53, 期 29, 页码 4152-4155出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc00247e
关键词
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资金
- Ministry of Science and Technology and Academia Sinica, Taiwan [105-0210-01-13-01, MOST-104-2113-M-001-015-MY3, MOST 105-2113-M-037-MY2, AS-105-TP-A04]
- Taiwan Ministry of Health and Welfare [CMRPG3C1141]
- Chang Gung Memorial Hospital [102-3107B]
- Academia Sinica [AS-IRB01-14031]
We design and synthesize EpCAM antibodies with Fc-domain site-specific linkers that allow preferential alignment when coated on microfluidic devices for capturing circulating tumor cells (CTCs) from colorectal cancer patients. The aligned coating is shown to increase the capture efficiency of CTCs and microemboli by 1.6 and 3.0-fold, respectively (both P < 0.05).
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