期刊
ACS NANO
卷 11, 期 4, 页码 3642-3650出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b07959
关键词
magnetic resonance imaging; contrast agents; nanoparticles; ligand effects; rare earths
类别
资金
- National Natural Science Foundation of China [21425101, 21321001, 21371011, 21331001, 91422302]
- National Basic Research Program of China [2014CB643800]
Magnetic resonance imaging contrast agents with both significantly enhanced relaxivity and minimal safety risk are of great importance for sensitive clinical diagnosis, but have rarely been reported. Herein, we present a simple strategy to improve relaxivity by introducing surface ligands with strong interaction to water molecules. As a proof of concept, NaGdF4 nanoparticles (NPs) capped by poly(acrylic acid) (PAA) show superior relaxivity to those capped by polyethylenimine and polyethylene glycol, which is attributed to the strong hydrogen-bond capacity of PAA to water molecules as revealed by theoretical calculation. Furthermore, benefiting from PAA and ultrasmall particle size, Gd-dots, namely PAA-capped GdOF NPs (2.1 +/- 0.2 nm), are developed as a high-performance contrast agent, with a remarkable ionic relaxivity of similar to 75 mM(-1) s(-1) in albumin solution at 0.5 T. These Gd-dots also exhibit efficient renal clearance with <3% of injected amount left 12 h post-injection. Ultrasensitive MR renography achieved with Gd-dots strongly suggests their great potential for practical applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据