期刊
EUROPEAN JOURNAL OF DERMATOLOGY
卷 27, 期 2, 页码 150-154出版社
JOHN LIBBEY EUROTEXT LTD
DOI: 10.1684/ejd.2016.2946
关键词
acitretin; psoriasis; total glucosides of paeony
类别
资金
- Shaanxi scientific research [2016KTZDSF02-05, 2016SF-374]
Background: Although acitretin has been widely used for the treatment of psoriasis, additional safer and more effective approaches, including traditional Chinese medicine, are needed. Objectives: To investigate the efficacy and safety of total glucosides of paeony (TGP) combined with acitretin in the treatment of moderate-to-severe plaque psoriasis. Materials & methods: A randomised, double-blind, placebo-controlled, multi-centre clinical study was conducted. In total, 108 patients with moderate-to-severe plaque psoriasis were randomly assigned to treatment with TGP plus acitretin (group A) or placebo plus acitretin (group B) for 12 weeks. Results: After 12 weeks of therapy, the percentage of patients achieving a 50% reduction in Psoriasis Area and Severity Index was 90% in group A and 70.5% in group B (p<0.05). The rate of serum alanine aminotransferase elevation was 6.25% in group A and 20.4% in group B (p<0.05). Conclusion: TGP is conducive to enhancing anti-psoriatic efficacy and reducing liver damage due to acitretin. TGP combined with acitretin is a safe and effective treatment approach for moderate-to-severe plaque psoriasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据