期刊
ALZHEIMERS RESEARCH & THERAPY
卷 9, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13195-017-0271-9
关键词
Alzheimer's disease; Cerebrovascular disease; Cerebrospinal fluid; Biomarkers; Age; Gender; APOE genotype
资金
- National Institute of Health [AG05136, AG023185, AG033693, AGO5131, AG08017]
- Royalty Research Fund
- anonymous foundation
- Nancy and Buster Alvord Endowment at the UW
Background: This study sought to evaluate gender and APOE genotype-related differences in the concentrations of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) and cerebrovascular injury across the life span of cognitively normal adults. Methods: CSF amyloid beta(1-42) (A beta(42)), phospho-tau-181 (p-tau(181)), and total tau were measured in 331 participants who were between the ages of 21 and 100. CSF E-selectin and vascular cell adhesion protein 1 (VCAM1) were measured in 249 participants who were between the ages of 50 and 100. Results: CSF total tau and p-tau(181) increased with age over the adult life span (p < 0.01) with no gender differences in those increases. CSF A beta(42) concentration varied according to age, gender, and APOE genotype (interaction of age x gender x epsilon 4, p = 0.047). CSF VCAM1, but not E-selectin, increased with age (p < 0.01), but both were elevated in men compared to women (p < 0.01). Conclusions: Female APOE-epsilon 4 carriers appear at higher risk for AD after age 50. In contrast, men may experience a relatively higher rate of cerebrovascular injury in middle and early old age.
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