期刊
CHEMICAL COMMUNICATIONS
卷 53, 期 40, 页码 5557-5560出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc01576c
关键词
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资金
- National Natural Science Foundation of China [81601605, 31525009, 81501572, 61427806]
- Sichuan Innovative Research Team Program for Young Scientists [2016TD0004]
- Shenzhen Basic Research Program [JCYJ20160422091418366]
- Natural Science Foundation of SZU [827-000143]
- Shenzhen Peacock Plan [KQTD2016053112051497]
- Fundamental Research Funds for the Shenzhen University, China [2016076]
- State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology [2017-KF-6]
A new H2O2-responsive nanomedicine for CO therapy is constructed by effectively encapsulating the hydrophobic manganese carbonyl prodrug into an advanced hollow mesoporous silica nanoparticle carrier to realize the intratumoral H2O2-triggered release of CO and selective killing of tumour cells rather than normal cells, exhibiting high in vitro and in vivo efficacies of CO therapy.
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