期刊
CHEMICAL COMMUNICATIONS
卷 53, 期 40, 页码 5519-5522出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc02842c
关键词
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资金
- NSF [DMR-1409335]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1409335] Funding Source: National Science Foundation
A photo-active luminescent rhenium carbonyl complex namely, [Re(CO)(3)(phen)(pyAl)](CF3SO3) was grafted on a biocompatible carboxymethyl chitosan (CMC) matrix through Schiff base condensation reaction. The light-induced CO delivery from ReCMC has been shown to eradicate human colorectal adenocarcinoma cells (HT-29) very efficiently in a dose-dependent fashion. The onset of CO-induced apoptosis was realized by caspase-3,-7 detection aided by fluorescence confocal microscopy. ReCMC represents a unique example of a biocompatible and biodegradable antineoplastic agent that could find its use in cancer photopharmacology.
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