期刊
ANALYTICA CHIMICA ACTA
卷 968, 期 -, 页码 1-20出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2017.03.021
关键词
Mass spectrometry; Chiral recognition; Enantiomeric excess (ee); Ion mobility
资金
- Collaborative Research Fund of Hong Kong Research Grants Council [C5031-14E]
- State Key Laboratory of Chirosciences
- The University Research Facility in Chemical and Environmental Analysis (UCEA) of The Hong Kong Polytechnic University
Chiral analysis is of great importance to fundamental and applied research in chemical, biological and pharmaceutical sciences. Due to the superiority of mass spectrometry (MS) over other analytical methods in terms of speed, specificity and sensitivity, chiral analysis by MS has attracted much interest in recent years. Chiral analysis by MS typically involves introduction of a chiral selector to form diastereomers with analyte enantiomers, and comparison of the behaviors of diastereomers in MS. Chiral differentiation can be achieved by comparing the relative abundances of diastereomers, the thermodynamic or kinetic constants of ion-molecule reactions of diastereomers in the gas phase, the dissociation of diastereomers in MS/MS, or the mobility of diastereomers in ion mobility mass spectrometry. In this review, chiral recognition and determination of enantiomeric excess by these chiral MS methods were summarized, and the prospects of chiral analysis by MS were discussed. (C) 2017 Elsevier B.V. All rights reserved.
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