期刊
FRONTIERS IN MEDICINE
卷 4, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmed.2017.00061
关键词
bronchopulmonary dysplasia; chronic lung disease of prematurity; respiratory distress syndrome; preterm birth; lung development; chronic lung disease
资金
- Sophia Children's Hospital Research Foundation [S16-17, S17-20, S15-11, S14-12, 678]
- Dirkje Postma Talent Award from Lung Foundation Netherlands [11.1.16.152]
- VENI grant from Dutch Scientific Organization (NWO)
- Lung Foundation Netherlands
Yearly more than 15 million babies are born premature (<37 weeks gestational age), accounting for more than 1 in 10 births worldwide. Lung injury caused by maternal chorioamnionitis or preeclampsia, postnatal ventilation, hyperoxia, or inflammation can lead to the development of bronchopulmonary dysplasia (BPD), one of the most common adverse outcomes in these preterm neonates. BPD patients have an arrest in alveolar and microvascular development and more frequently develop asthma and early-onset emphysema as they age. Understanding how the alveoli develop, and repair, and regenerate after injury is critical for the development of therapies, as unfortunately there is still no cure for BPD. In this review, we aim to provide an overview of emerging new concepts in the understanding of perinatal lung development and injury from a molecular and cellular point of view and how this is paving the way for new therapeutic options to prevent or treat BPD, as well as a reflection on current treatment procedures.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据